Erythrocyte Glutathione Peroxidase, Serum Selenium, Lipids and Lipoproteins in Human Immunodeficiency Virus Positive Blood Donors

The study was designed to assess the relationship between red cell glutathione peroxidase and serum selenium as well as lipids and lipoprotein in HIV positive blood donors. Thirty five subjects consisting of twenty HIV positive blood donors with a mean age of 34±2.18 years and fifteen HIV negative blood donors with a mean age of 43±2.18 years controls were selected for this study. Erythrocyte glutathione peroxidase, lipids and lipoprotein were estimated using colorimetric methods. Serum selenium was determined by atomic absorption spectrophotometer. The anthropometric indices were determined using standard techniques. The mean body mass index was significantly reduced in HIV patients when compared with the controls. Significant decreased mean value was obtained in the erthrocyte glutathione peroxidase (p<0.01) while significant increases were observed in serum triglycerides (p<0.01) and total cholesterol (p<0.05) compared with the control values. Erythrocyte glutathione peroxidase was significantly correlated with total cholesterol (r = 0.603, p<0.05) and low density lipoprotein cholesterol (r = 0.605, p<0.05). Decreased cellular antioxidant such as erythrocyte glutathione peroxidase, increased TC and TG were observed in HIV positive blood donors in the present study.